West Brom midfielder Jake Livermore has
been called up as a replacement.
Striker Kane has a knee injury while
midfielder Winks has an ankle problem. The
pair had treatment during the 1-0 win over
Crystal Palace on Sunday.
England host Germany at Wembley on Friday
and then play Brazil at the same venue on
14 November.
Kane and Winks' Spurs team-mate Dele Alli
had already withdrawn from the original
squad and on Monday England called up
Everton defender Michael Keane to replace
him.
Tottenham boss Mauricio Pochettino said
Winks, who went off at half-time in the
Palace match, had twisted his ankle.
Kane received treatment on his knee in the
first half and was substituted on 77 minutes
for "protection", according to Pochettino.
Chelsea centre-back Gary Cahill, who helped
his side beat Manchester United on Sunday,
will also be assessed by his club before
joining up with the national team.
Midfielder Jordan Henderson missed
Liverpool's victory over West Ham with a
thigh problem but is due to arrive at St
George's Park later in the week.